(1) The effectiveness of the site of action. The traditional antibiotics achieve the purpose of sterilization by eliminating the necessary functions of micro growth or survival, such as obstructing the synthesis of bacterial proteins or changing the activity of enzymes, while it is enough for bacteria to change a certain gene to cope with this kind attack of antibiotics. Antimicrobial peptides act on the bacterial cell membrane, resulting in an increase in the permeability of the membrane, to penetrate and kill bacteria. B must change the structure of the membrane, that is, change a considerable part of the genes in order to defend against the attack of antimicrobial peptides, which is almost. Therefore, antimicrobial peptides greatly reduce the possibility of developing drug resistance. (2) The selectivity of the target. Antimicrobial peptides antibacterial effects only on prokaryotic cells and pathological cells of eukaryotic cells, but not on normal eukaryotic cells. The reason is that the membrane structure of prokaryotes and eukaryotes is different, and the eukaryotic cell membrane contains a large amount of cholesterol, and the existence of cholesterol makes membrane structure tend to be stable. In addition, higher animals have a highly developed cytoskeleton system, whose existence also resists the action of antimicrobial peptides The cytoskeleton system of cancer cells is not well developed compared with normal cells, which is one of the reasons why antimicrobial peptides have an inhibitory effect them.